Oprah, Burns Again Make 50 Most Powerful Women in Business List

This marks the 10th year Fortune has done the rankings which takes into consideration, company size and health, career momentum, and social and cultural influence. The credentials of this year's top 50, including 13 newcomers but only two black women.

Burns, ranked 11th this year, up from 27th last year, is not only the heir apparent and right-hand woman to Xerox CEO Anne Mulcahy, but the force behind the improved product line at Xerox. One example of the fruits of Burns' R&D investments: Xerox's new emulsion aggregate toner plant in upstate New York, which opened in August, is the only one of its kind in the U.S.

Winfrey's cultural clout is undeniable. Her Oscar special this year was among the top-rated shows that week, and in a tough year for magazines, O: The Oprah Magazine saw ad pages rise 14%. She's ranked 8th this year, the same place she held last year.

Topping the list for two years in a row is Indra Nooyi, CEO of PepsiCo. Xerox CEO Anne Mulcahy is ranked second, the same as last year.